BDBM743458 US20250163072, Example RM351

SMILES CC(C)[C@@H](C(=O)N[C@H]1Cc2cc(O)cc(c2)-c2ccc3c(C(C)(C)C#N)cn(c3c2)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)N1CCCC2(CCN(C(=O)CCl)C2)C1=O

InChI Key InChIKey=YVOCKDYWYDWNQQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 743458   

TargetGTPase KRas [G12C]/Serine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743458(US20250163072, Example RM351)
Affinity DataIC50: 1.79E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743458(US20250163072, Example RM351)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743458(US20250163072, Example RM351)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743458(US20250163072, Example RM351)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent