BDBM743456 US20250163072, Example RM018

SMILES CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCN(C(=O)C#CCN3CCOCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2

InChI Key InChIKey=RGBJDHBYYMZUII-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 743456   

TargetGTPase KRas [G12C]/Serine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743456(US20250163072, Example RM018)
Affinity DataIC50: 268nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743456(US20250163072, Example RM018)
Affinity DataIC50: 25nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743456(US20250163072, Example RM018)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM743456(US20250163072, Example RM018)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2025
Entry Details
Go to US Patent