BDBM740861 Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1,1-trifluoropropan-2-yl)amino)-1,3,5-triazin-2-yl-pyridin-2-yl)thio)propanoic acid ::US12303512, Compound 5

SMILES C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(-c2cccc(SC[C@H](N)C(=O)O)n2)n1)C(F)(F)F

InChI Key InChIKey=OWHJDIRCQHWUSF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 740861   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740861(Preparation of (R)-2-amino-3-((6-(4,6-bis(((R)-1,1...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent