BDBM740766 Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropropan-2-yl)amino)-1,3,5-triazin-2-yl)pyridine-2-thiol ::US12303512, Compound 3

SMILES C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(-c2cccc(S)n2)n1)C(F)(F)F

InChI Key InChIKey=RXRVZRQOGSLLSY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 740766   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 5.55E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 1.26E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 576nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 711nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 5.06E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 2.34E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740766(Preparation of 6-(4, 6-bis(((R)-1,1,1-trifluoropro...)
Affinity DataIC50: 1.56E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent