BDBM740764 Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine ::US12303512, Compound 1

SMILES CSc1cccc(-c2nc(N[C@H](C)C(F)(F)F)nc(N[C@H](C)C(F)(F)F)n2)n1

InChI Key InChIKey=KUNRVODWGULPIF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 740764   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 1.59E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 36nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 37nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 193nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandPNGBDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent