BDBM740589 8-methyl-3-[(3S)-tetrahydrofuran-3- yl]oxy-N-[(1R)-1-[3- (trifluoromethyl)phenyl]ethyl]pyrido[2,3- d]pyridazin-5-amine::US20250154147, Example 10

SMILES Cc3nnc(N[C@H](C)c1cccc(C(F)(F)F)c1)c4cc(O[C@H]2CCOC2)cnc34

InChI Key InChIKey=NLOCFTOQHRXKBN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740589   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740589(8-methyl-3-[(3S)-tetrahydrofuran-3- yl]oxy-N-[(1R)...)
Affinity DataIC50: 174nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/16/2025
Entry Details
Go to US Patent