BDBM7377 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol::6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 39::7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine::CHEMBL75680::aloisine A

SMILES CCCCc1c([nH]c2nccnc12)-c1ccc(O)cc1

InChI Key InChIKey=PRIGRJPRGZCFAS-UHFFFAOYSA-N

Data  14 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 7377   

TargetGlycogen synthase kinase-3 alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 650nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 646nMAssay Description:Inhibitory concentration against Glycogen synthase kinase-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 650nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataEC50:  111nMAssay Description:Activity at human wild type CFTR expressed in F508del-CF1 cells assessed as forskolin stimulated iodide fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Baker's yeast)
Cnrs Usr-3151

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of hemagglutininin-tagged Saccharomyces cerevisiae MNY629 Cdc28/Clb2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Cnrs Usr-3151

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 200nMAssay Description:Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 200nMAssay Description:Inhibition of cyclin-dependent kinase 5/p25; range 0.16-0.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataEC50:  140nMAssay Description:Activity at human wild type CFTR expressed in Calu3 cells assessed as forskolin stimulated iodide fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataEC50:  150nMAssay Description:Activity at human wild type CFTR expressed in CHO cells assessed as forskolin stimulated iodide fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 150nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(CHEMBL75680 | aloisine A | 7-n-Butyl-6-(4-hydroxyp...)
Affinity DataIC50: 650nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed