BDBM7336 13-bromo-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}.0^{11,16}]heptadeca-1(10),2(6),4,11(16),12,14-hexaen-8-one::8-Bromo-6,11-dihydro-thieno[3 ,2 :2,3]azepino[4,5-b]indol-5(4H)-one::NSC 703058::Paullone Analogue 71::Thieno analogue of kenpaullone

SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1

InChI Key InChIKey=XLKHCIUFNPNLIE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 7336   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Universitat Hamburg

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 600nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Universitat Hamburg

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 600nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Technische Universitat Braunschweig

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 4.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Technische Universitat Braunschweig

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 120nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Technische Universitat Braunschweig

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 4.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Technische Universitat Braunschweig

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 120nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Technische Universitat Braunschweig

LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 120nMAssay Description:Inhibition of rat GSK3beta expressed in Sf9 cells incubated for 30 mins using GS-1 peptide substrate and [gamma-32P]ATP by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Babasaheb Bhimrao Ambedkar University

Curated by ChEMBL
LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 600nMAssay Description:Inhibition of GST-tagged CDK1/cyclin B (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7336(Paullone Analogue 71 | 13-bromo-3-thia-7,17-diazat...)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed