BDBM73346 3-(1H-indol-3-yl)-2,5-pyrrolidinedione::3-(1H-indol-3-yl)pyrrolidine-2,5-dione::3-(1H-indol-3-yl)pyrrolidine-2,5-quinone::MLS000099368::SMR000071516::US9603836, Compound 3::US9949951, 3::cid_363326

SMILES O=C1CC(C(=O)N1)c1c[nH]c2ccccc12

InChI Key InChIKey=VNQNEQQYAIPCAQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 73346   

TargetProtein LANA1(HHV-8)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM73346(MLS000099368 | SMR000071516 | cid_363326 | 3-(1H-i...)
Affinity DataEC50: >7.50E+4nMAssay Description:Primary Collaborators: Kenneth Kaye,Brigham & Womens,Boston MA,kkaye@rics.bwh.harvard.edu,617-525-4256 Chantal Beauchemin,Brigham & Womens,Boston MA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM73346(MLS000099368 | SMR000071516 | cid_363326 | 3-(1H-i...)
Affinity DataIC50: 3.00E+3nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM73346(MLS000099368 | SMR000071516 | cid_363326 | 3-(1H-i...)
Affinity DataIC50: 3.00E+3nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM73346(MLS000099368 | SMR000071516 | cid_363326 | 3-(1H-i...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed