BDBM7304 14-bromo-18-(prop-2-en-1-yl)-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::9-bromo-12-(2-propenyl)-paullone::CHEMBL99280::NSC 704072::Paullone Analog 43

SMILES Brc1ccc2n(CC=C)c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI Key InChIKey=GJZCFRVBDYYNIV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7304   

LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 6.00E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 2.40E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 4.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
UniversitäT Hamburg

Curated by ChEMBL
LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 6.00E+4nMAssay Description:In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM7304(9-bromo-12-(2-propenyl)-paullone | NSC 704072 | CH...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of GSK3-beta expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed