BDBM726567 US20250084039, Compound HSN431

SMILES CC1=NC=C(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)CC1C#CC1=C2C=C(F)C=CC2CN=C1N

InChI Key InChIKey=WWFDZOREBFAYLO-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726567   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726567(US20250084039, Compound HSN431)
Affinity DataKd:  4.80nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726567(US20250084039, Compound HSN431)
Affinity DataKd:  57nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent