BDBM726105 US20250074920, Compound 10::[3a(4)Z,10R]-6,9,10,15-tetramethyl-3,8- dioxo-3,5,8,9,10,11,13,15-octahydro-2H- 1,17-(ethanediylidene)pyrazolo[4,3- m]dipyrrolo[3,2-f:3',4'- i][1,4]oxazacyclopentadecine-20- carbonitrile

SMILES Cc3cc2C(=O)N(C)[C@H](C)COCc1nn(C)cc1c5cc(C#N)c4[nH]c(=O)c(=Cc2[nH]3)c4c5

InChI Key InChIKey=UPGYLNNCCRAXDB-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 726105   

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726105([3a(4)Z,10R]-6,9,10,15-tetramethyl-3,8- dioxo-3,5,...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726105([3a(4)Z,10R]-6,9,10,15-tetramethyl-3,8- dioxo-3,5,...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 Protein [521-781](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726105([3a(4)Z,10R]-6,9,10,15-tetramethyl-3,8- dioxo-3,5,...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726105([3a(4)Z,10R]-6,9,10,15-tetramethyl-3,8- dioxo-3,5,...)
Affinity DataKd:  46nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent