BDBM726101 US20250074920, Compound 6::[3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,11,13,15-tetrahydro-2H- 1,17-(ethanediylidene)pyrazolo[4,3- m]dipyrrolo[3,2-f:3',4'- i][1,4]oxazacyclopentadecine- 3,8(5H,9H)-dione

SMILES Cc3cc2C(=O)N(C)[C@@H](C)COCc1nn(C)cc1c5cc(Cl)c4[nH]c(=O)c(=Cc2[nH]3)c4c5

InChI Key InChIKey=TYZYHIAKKRJCBW-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 726101   

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd:  160nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 Protein [521-781](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726101([3a(4)Z,10S]-20-chloro-6,9,10,15- tetramethyl-10,1...)
Affinity DataKd:  2.5nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent