BDBM726096 US20250074920, Compound 1::[3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahydro-15H-1,17- (ethanediylidene)pyrazolo[4,3- n]dipyrrolo[3,2-g:3',4'- j][1,5]oxazacyclopentadecine- 3,8(2H,5H)-dione

SMILES Cc1cc2c([nH]1)/C=C1C(=O)Nc3ccc(cc31)-c1c(nn(C)c1C)OCCCN(C)C2=O

InChI Key InChIKey=LGBDEZIXAMATRP-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 726096   

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726096([3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726096([3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 Protein [521-781](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726096([3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726096([3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM726096([3a(4)Z]-6,9,15,16-tetramethyl- 9,10,11,12-tetrahy...)
Affinity DataKd:  220nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent