BDBM725786 US20250074911, Example 9

SMILES CN1C/C=C/c2cnc(N)c3c(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)nn(c23)[C@@H]2CCC[C@H](C2)NC(=O)C1

InChI Key InChIKey=JTXABXJNLKWUSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 725786   

TargetTyrosine-protein kinase BTK(Human)
Crossfire Oncology Holding

US Patent
LigandPNGBDBM725786(US20250074911, Example 9)
Affinity DataIC50: 5nMAssay Description:To determine the inhibitory activity of compounds on wt-BTK enzyme activity, the IMAP® assay (Molecular Devices) was used. Compounds were serially di...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Crossfire Oncology Holding

US Patent
LigandPNGBDBM725786(US20250074911, Example 9)
Affinity DataIC50: 5nMAssay Description:To determine the inhibitory activity of compounds on BTK C481S enzyme activity, the IMAP® assay (Molecular Devices) was used. Compounds were serially...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent