BDBM725407 3-(3-((4-chlorobenzyl)oxy)-4-((2,2,2- trifluoroethyl)sulfonamido)phenyl)-5- ((5-methoxypyrazin-2-yl)amino)-1H- pyrazole-4-carboxamide::US20250074891, Compound 157

SMILES COc1cnc(Nc2[nH]nc(-c3ccc(NS(=O)(=O)CC(F)(F)F)c(OCc4ccc(Cl)cc4)c3)c2C(N)=O)cn1

InChI Key InChIKey=VJJINUFTKABRMF-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 725407   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725407(3-(3-((4-chlorobenzyl)oxy)-4-((2,2,2- trifluoroeth...)
Affinity DataKd: <10nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725407(3-(3-((4-chlorobenzyl)oxy)-4-((2,2,2- trifluoroeth...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725407(3-(3-((4-chlorobenzyl)oxy)-4-((2,2,2- trifluoroeth...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent