BDBM725258 3-(4- (ethylsulfon- amido)- 3-((4- fluoro- benzyl)oxy) phenyl)- 5-((6- (trifluoro- methyl) pyridin- 2-yl) amino)-1H- pyrazole-4- carboxamide::US20250074891, Compound 8

SMILES CCS(=O)(=O)Nc1ccc(-c2n[nH]c(Nc3cccc(C(F)(F)F)n3)c2C(N)=O)cc1OCc1ccc(F)cc1

InChI Key InChIKey=ISMUHWRSYGSKIB-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 725258   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725258(3-(4- (ethylsulfon- amido)- 3-((4- fluoro- benzyl)...)
Affinity DataKd:  505nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725258(3-(4- (ethylsulfon- amido)- 3-((4- fluoro- benzyl)...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725258(3-(4- (ethylsulfon- amido)- 3-((4- fluoro- benzyl)...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent