BDBM725201 (2S,3S,4S,5R)-4-(3-chloro-2-fluorophenyl)-N-(4-((S)-1-((2-((S)-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)-6-azaspiro[2.5]octane-6-carbonyl)-2-methoxyphenyl)-2-neopentyl-6'-(trifluoromethyl)-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide::US20250073340, Example 56

SMILES COc1cc(C(=O)N2CCC3(CC2)C[C@@H]3C#Cc2cccc3c2CN([C@H]2CCC(=O)NC2=O)C3=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(C(F)(F)F)ncc32)[C@H]1c1cccc(Cl)c1F

InChI Key InChIKey=ATUTWMIBPYSOCC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725201   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725201((2S,3S,4S,5R)-4-(3-chloro-2-fluorophenyl)-N-(4-((S...)
Affinity DataIC50: 23.4nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
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