BDBM725193 (2'S,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)-7-azaspiro[3.5]nonane-7-carbonyl)-2-methoxyphenyl)-2'-neopentylspiro[indoline-3,3'-pyrrolidine]-5'-carboxamide::US20250073340, Example 42

SMILES COc1cc(C(=O)N2CCC3(CC2)CC(C#Cc2cccc4c2CN(C2CCC(=O)NC2=O)C4=O)C3)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F

InChI Key InChIKey=PSDVCWAVZUVVAE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725193   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725193((2'S,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 4.51nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
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