BDBM725161 US20250073340, Example 7:: (2'S,3S,4'S,5'R)—N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-5'-methyl-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

SMILES COc1cc(C(N)=O)ccc1NC(=O)[C@]1(C)N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F

InChI Key InChIKey=WBJKKMNFNMNHSH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725161   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725161( (2'S,3S,4'S,5'R)—N-(4-carbamoyl-2-methoxyphenyl)-...)
Affinity DataIC50: 97.6nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent