BDBM7250 (3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-yl}methylidene)-4-(piperidin-4-yl)-2,3-dihydro-1H-indol-2-one::pyrrollylactone indolinone driv. 15l

SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCOC2=O

InChI Key InChIKey=GHRJDUDIROBWRM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7250   

LigandPNGBDBM7250((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7250((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Affinity DataIC50: 490nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7250((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Affinity DataIC50: 1.10E+3nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7250((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Affinity DataIC50: 1.10E+3nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed