BDBM724594 N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl]methyl}-2-(morpholin-4-yl)-7-(trifluoromethyl)imidazo[2,1-f][1,2,4]triazin-4-amine::US20250066370, Example 18

SMILES COc1ccc(-c2nnc(CNc3nc(N4CCOCC4)nn4c(C(F)(F)F)cnc34)[nH]2)cn1

InChI Key InChIKey=GPEKIJBCARMNSZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 724594   

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724594(N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-y...)
Affinity DataIC50: 41.6nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724594(N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-y...)
Affinity DataIC50: 5.71E+3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724594(N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-y...)
Affinity DataIC50: 340nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent