BDBM724593 2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyridin-3-yl]-4H-1,2,4-triazol-3-yl}methyl)-8-(trifluoromethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine::US20250066370, Example 17

SMILES FC(F)(F)Oc1ccc(-c2nnc(CNc3nc(N4CCOCC4)nc4c(C(F)(F)F)cnn34)[nH]2)cn1

InChI Key InChIKey=FGUMMJQRCUJATR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 724593   

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724593(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 5.96nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724593(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 6.72E+3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent