BDBM724577 (2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dihydroxy-N-(methyl-D3)-5-oxo-1-(4-(trifluoromethyl)selenophenyl[2,3-b]pyridin-6-yl)pyrrolidine-2-carboxamide ::US20250066368, Compound 46

SMILES [2H]C([2H])([2H])N(C(=O)[C@@H]1[C@H](O)[C@H](O)C(=O)N1c1cc(C(F)(F)F)c2cc[se]c2n1)c1cc(Cl)c(F)cc1F

InChI Key InChIKey=FRPLQMSSVKEYRQ-FIBGUPNXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 724577   

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724577((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent