BDBM724572 US20250066368, Compound 37::{(2S,3S,4S)-1-[7,7-difluoro-4-(trifluoromethyl)(5,6,7-trihydrocyclopenta[1,2-e]pyridin-2-yl)]-3,4-dihydroxy-5-oxopyrrolidin-2-yl}-N-(5-chloro-2,4-difluorophenyl)-N-methylformamide

SMILES O=C1[C@@H](O)[C@@H](O)[C@@H](C(=O)N(c2cc(Cl)c(F)cc2F)C(F)(F)F)N1c1cc(C(F)(F)F)c2c(n1)C(F)(F)CC2

InChI Key InChIKey=OSBWQCSHYBDGIN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 724572   

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724572({(2S,3S,4S)-1-[7,7-difluoro-4-(trifluoromethyl)(5,...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
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