BDBM724569 (R)-4-(1-(3-chloro-4-fluorophenyl)-4-fluoro-1H-imidazol-2-yl)-3-(4-(trifluoromethyl)thieno[2,3-b]pyridin-6-yl)oxazolidin-2-one ::US20250066368, Compound 30

SMILES O=C1OC[C@@H](c2nc(F)cn2-c2ccc(F)c(Cl)c2)N1c1cc(C(F)(F)F)c2ccsc2n1

InChI Key InChIKey=HFFMWZRFSZVPOY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 724569   

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724569((R)-4-(1-(3-chloro-4-fluorophenyl)-4-fluoro-1H-imi...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
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