BDBM724498 7-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoromethyl)phenyl)propyl)piperazin-1-yl)-4-methyl-3-(((R)-tetrahydrofuran-2-yl)methyl)-3,4-dihydro-5H-[1,2,3]triazolo[4,5-d]pyrimidin-5-one::US20250066363, Example 30

SMILES CC[C@@H]4CN(c1nc(=O)n(C)c2c1nnn2C[C@H]3CCCO3)[C@@H](C)CN4[C@@H](CC)c5ccc(C(F)(F)F)cc5

InChI Key InChIKey=LRIPHWUPSSMOTL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 724498   

TargetDiacylglycerol kinase alpha(Human)
Incyte

US Patent
LigandPNGBDBM724498(7-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:For compound inhibition studies, 40 nL test compound in DMSO was added to wells of white polystyrene plates in 384-well (Greiner, #784075) or 1536-we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Incyte

US Patent
LigandPNGBDBM724498(7-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:For compound inhibition studies, 40 nL test compound in DMSO was added to wells of white polystyrene plates in 384-well (Greiner, #784075) or 1536-we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent