BDBM724490 US20250066363, Example 22::or 23. 7-((2S,5R)-4-((S)-(4-Chlorophenyl)((S)-2,2-difluorocyclopropyl)methyl)-5-ethyl-2-methylpiperazin-1-yl)-4-methyl-3-(((R)-tetrahydrofuran-2-yl)methyl)-3,4-dihydro-5H-[1,2,3]triazolo[4,5-d]pyrimidin-5-one or 7-((2S,5R)-4-((R)-(4-chlorophenyl)((S)-2,2-difluorocyclopropyl)methyl)-5-ethyl-2-methylpiperazin-1-yl)-4-methyl-3-(((R)-tetrahydrofuran-2-yl)methyl)-3,4-dihydro-5H-[1,2,3]triazolo[4,5-d]pyrimidin-5-one

SMILES CC[C@@H]1CN(c2nc(=O)n(C)c3c2nnn3C[C@H]2CCCO2)[C@@H](C)CN1[C@H](c1ccc(Cl)cc1)[C@@H]1CC1(F)F

InChI Key InChIKey=PAJCZDCGGGKXCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 724490   

TargetDiacylglycerol kinase alpha(Human)
Incyte

US Patent
LigandPNGBDBM724490(or 23. 7-((2S,5R)-4-((S)-(4-Chlorophenyl)((S)-2,2-...)
Affinity DataIC50: 10nMAssay Description:For compound inhibition studies, 40 nL test compound in DMSO was added to wells of white polystyrene plates in 384-well (Greiner, #784075) or 1536-we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Incyte

US Patent
LigandPNGBDBM724490(or 23. 7-((2S,5R)-4-((S)-(4-Chlorophenyl)((S)-2,2-...)
Affinity DataIC50: 100nMAssay Description:For compound inhibition studies, 40 nL test compound in DMSO was added to wells of white polystyrene plates in 384-well (Greiner, #784075) or 1536-we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent