BDBM723425 US12234230, Compound 38

SMILES C[C@H]1CCCN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc([C@]4(c5nncn5C)C[C@@H](C#N)C4)c2)C3=O)C1

InChI Key InChIKey=ZGRPNUPETHACEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 723425   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Nurix Therapeutics

US Patent
LigandPNGBDBM723425(US12234230, Compound 38)
Affinity DataIC50: 5nMAssay Description:Table 2: Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 54). Cbl-b displacement assays were performed in a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Nurix Therapeutics

US Patent
LigandPNGBDBM723425(US12234230, Compound 38)
Affinity DataIC50: 27.5nMAssay Description:Table 8-1: Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL. Cbl-b displacement assays were performed in a 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Nurix Therapeutics

US Patent
LigandPNGBDBM723425(US12234230, Compound 38)
Affinity DataIC50: 27.5nMAssay Description:Table 11-1: Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL. Cbl-b displacement assays were performed in a 384-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
Go to US Patent