BDBM722663 N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl- piperidin-4-yl)- 1H-pyrazol-4-yl)- 1-methyl-1H- pyrazolo[4,3-c] pyridin-3-yl)-2- ((S)-1-(4- fluorophenyl) ethoxy)phenyl)- 1,1- difluoromethane- sulfonamide::US20250059188, Compound 158::US20250115598, Compound 158

SMILES C[C@H](Oc1cc(-c2nn(C)c3c(-c4cnn(C5CCN(C)C(C(F)F)C5)c4)cnc(N)c23)ccc1NS(=O)(=O)C(F)F)c1ccc(F)cc1

InChI Key InChIKey=YFRBLJSPBMQDKG-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 722663   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd:  50.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd: >2.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722663(N-(4-(4- amino-7-(1-(2- (difluoromethyl)- 1-methyl...)
Affinity DataKd: >2.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent