BDBM722405 (E)-1-(2-(2-((2,6-dimethyl-4-(trifluoromethyl)phenyl)imino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea ::US20250059186, Compound 2

SMILES COc4cc3CCn2c(cc(=Nc1c(C)cc(C(F)(F)F)cc1C)n(CCNC(N)=O)c2=O)c3cc4OC

InChI Key InChIKey=REZFWHGMIXRYPW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 722405   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Xizang Haisco Pharmaceutical

US Patent
LigandPNGBDBM722405((E)-1-(2-(2-((2,6-dimethyl-4-(trifluoromethyl)phen...)
Affinity DataIC50: 75nMAssay Description:1) Prepare FAM cAMP working solution: 20 μL of FAM-Cyclic-3′, 5′-AMP stock was added to 1980 μL of PDE assay buffer. The mixture was added to all wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent