BDBM721559 US20250059159, Compound 67::methyl (E)-4-(2-(2-((1-((R)-1-(naphthalen-1-yl)ethyl)piperidin-4-yl)((E)-4,4,4-trifluoro-3-oxobut-1-en-1-yl)amino)acetamido)acetamido)but-2-enoate

SMILES COC(=O)/C=C/CNC(=O)CNC(=O)CN(/C=C/C(=O)C(F)(F)F)C3CCN([C@H](C)c1cccc2ccccc12)CC3

InChI Key InChIKey=CMZGWFJYYVAJGA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 721559   

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Synergy Pharmaceutical Sciences

US Patent
LigandPNGBDBM721559(methyl (E)-4-(2-(2-((1-((R)-1-(naphthalen-1-yl)eth...)
Affinity DataIC50: 100nMAssay Description:The PLpro enzyme was purified as described above and prepared in assay buffer (50 mM HEPES, pH 7.5, 0.01% Triton X-100 (v/v), 0.1 mg mL-1 BSA, and 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent