BDBM721476 US12227517, Example 82

SMILES CN(C)[C@@H]5CCN6CCN(c4c(NC(=O)c2csc(c1ccnnc1)n2)ccc(OC3CC3)c4C(F)(F)F)C[C@@H]56

InChI Key InChIKey=NKPULJZBSSJDBM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 721476   

TargetDiacylglycerol kinase epsilon(Human)
Astellas Pharma

US Patent
LigandPNGBDBM721476(US12227517, Example 82)
Affinity DataIC50: 3nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK Δ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1 mM dithio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent