BDBM721442 US12227517, Example 48

SMILES NC[C@H]1CCCN1c1c(NC(=O)c2csc(-c3ccnnc3)n2)ccc(Oc2ccccc2F)c1C(F)(F)F

InChI Key InChIKey=QRZMKBCIECANSD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 721442   

TargetDiacylglycerol kinase epsilon(Human)
Astellas Pharma

US Patent
LigandPNGBDBM721442(US12227517, Example 48)
Affinity DataIC50: 8nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK Δ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1 mM dithio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent