BDBM721405 US12227517, Example 17

SMILES Cn1ccc(Oc2ccc(NC(=O)c3csc(-c4ccnnc4)n3)c(N3CCC[C@@H](CN)C3)c2C(F)(F)F)n1

InChI Key InChIKey=VGXILFJMIRBOJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 721405   

TargetDiacylglycerol kinase epsilon(Human)
Astellas Pharma

US Patent
LigandPNGBDBM721405(US12227517, Example 17)
Affinity DataIC50: 13nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK Δ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1 mM dithio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent