BDBM720779 Synthesis of (R)-4-phenyl-1-((R)-2-(pyrazine-2-carboxamido)-3-(thiazol-2-yl) propanamido) butyl)boronic acid (Compound 1) and ((R)-4-phenyl-1-((S)-2-(pyrazine-2-carboxamido)-3-(thiazol-2-yl)propanamido)butyl)boronic acid ::US20250051367, Compound 2

SMILES O=C(N[C@@H](Cc1nccs1)C(=O)N[C@@H](CCCc1ccccc1)B(O)O)c1cnccn1

InChI Key InChIKey=FPCOSVYXMMAXRQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 720779   

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720779(Synthesis of (R)-4-phenyl-1-((R)-2-(pyrazine-2-car...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
6/17/2025
Entry Details
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