BDBM719769 2-hydroxy-N-((5-(2-((6- (trifluoromethyl)oxazolo[5,4- c]pyridin-2- yl)thio)acetyl)thiophen-2- yl)methyl)acetamide::US20250051319, Compound 71

SMILES O=C(CO)NCc1ccc(C(=O)CSc2nc3cc(C(F)(F)F)ncc3o2)s1

InChI Key InChIKey=MWSRLLCCKLCXEI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 719769   

TargetHistone deacetylase 6 [482-800](Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719769(2-hydroxy-N-((5-(2-((6- (trifluoromethyl)oxazolo[5...)
Affinity DataIC50: 100nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6 [482-800](Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719769(2-hydroxy-N-((5-(2-((6- (trifluoromethyl)oxazolo[5...)
Affinity DataIC50: 100nMAssay Description:Dose response testing of HDAC6 and HDAC 1 were run at Reaction Biology Corporation (RBC). Inhibition of HDAC enzymes was performed using N-terminal G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719769(2-hydroxy-N-((5-(2-((6- (trifluoromethyl)oxazolo[5...)
Affinity DataIC50: 2.17E+3nMAssay Description:Dose response testing of HDAC6 and HDAC 1 were run at Reaction Biology Corporation (RBC). Inhibition of HDAC enzymes was performed using N-terminal G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent