BDBM719704 N-((5-(2-((2-methylquinazolin-4- yl)thio)acetyl)thiophen-2- yl)methyl)pivalamide::US20250051319, Compound 3

SMILES Cc1nc(SCC(=O)c2ccc(CNC(=O)C(C)(C)C)s2)c2ccccc2n1

InChI Key InChIKey=CEEPNIJZEHOZOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 719704   

TargetHistone deacetylase 6 [482-800](Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719704(N-((5-(2-((2-methylquinazolin-4- yl)thio)acetyl)th...)
Affinity DataIC50: 100nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6 [482-800](Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719704(N-((5-(2-((2-methylquinazolin-4- yl)thio)acetyl)th...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6 [482-800](Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719704(N-((5-(2-((2-methylquinazolin-4- yl)thio)acetyl)th...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent