BDBM719702 6-((1H-pyrazol-4-yl)sulfonyl)-2-((1-cyclopropyl-1H-pyrazol-3-yl)methyl) phthalazin-1(2H)-one::US20250051313, Example 1

SMILES O=c1c2ccc(S(=O)(=O)c3cn[nH]c3)cc2cnn1Cc1ccn(C2CC2)n1

InChI Key InChIKey=VRODYHUJAKVDCG-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719702   

TargetPyruvate kinase PKM(Human)
Sitryx Therapeutics

US Patent
LigandPNGBDBM719702(6-((1H-pyrazol-4-yl)sulfonyl)-2-((1-cyclopropyl-1H...)
Affinity DataEC50:  64.5nMAssay Description:Human PKM2 was diluted into Assay Buffer comprising 50 mM imidazole, 50 mM KCl, 7 mM MgCl2, 0.01% Tween20, 0.05% BSA (pH 7.2) to a final concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetPyruvate kinase PKLR(Human)
Sitryx Therapeutics

US Patent
LigandPNGBDBM719702(6-((1H-pyrazol-4-yl)sulfonyl)-2-((1-cyclopropyl-1H...)
Affinity DataEC50:  10.3nMAssay Description:Human PKLR was diluted into Assay Buffer to a final concentration of 5 pM. Enzyme-Assay Buffer mix was dispensed into 384-well shallow-well white-wal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent