BDBM719674 3-(3-chloro-4-((1S,2S)-2-(3-(cyclopropylcarbamoyl)-5-fluorophenyl)cyclopropyl)-::US20250051309, Example 16.1

SMILES Cc1cnc(-c2cccc(C(=O)N(C)C)c2F)cc1-n1c(C)cc([C@H]2C[C@@H]2c2cc(F)cc(C(=O)NC3CC3)c2)c(Cl)c1=O

InChI Key InChIKey=KNZHZDWUGNKVCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719674   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719674(3-(3-chloro-4-((1S,2S)-2-(3-(cyclopropylcarbamoyl)...)
Affinity DataIC50: 1.70nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM719674(3-(3-chloro-4-((1S,2S)-2-(3-(cyclopropylcarbamoyl)...)
Affinity DataIC50: 3.5nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent