BDBM719104 US12221453, Compound I-48

SMILES CNc1cc(Nc2cccn(C3CC(F)(F)C3)c2=O)nc2c(C(=O)NC3CC[C@H]3OC)cnn12

InChI Key InChIKey=ZIFMPGSWUCXXOI-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719104   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM719104(US12221453, Compound I-48)
Affinity DataKd:  0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMVEscan® assay (D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent