BDBM719003 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-N-(4-[[(2S)-1,4-dioxan-2-ylmethyl]amino]-3-nitrobenzene sulfonyl)-2-[(12R)-12-methyl-13-oxa-2,4,10-triazatricyclo[7.4.0.0{circumflex over ( )}[3,7]]trideca-1(9),2,5,7-tetraen-10-yl]benzamide::US12220419, Example 60

SMILES C[C@@H]1CN(c2ccc(N3CCN(CC4=CCC(C)(C)CC4c4ccc(Cl)cc4)CC3)cc2C(=O)NS(=O)(=O)c2ccc(NC[C@H]3COCCO3)c([N+](=O)[O-])c2)c2cc3cc[nH]c3nc2C1=O

InChI Key InChIKey=DSNMJESJNZHPHZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719003   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM719003(4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)
Affinity DataIC50: 0.400nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent