BDBM719002 (2S,4R)-1-[(2S)-2-[3-[2-(2-[2-[(4-[[5-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]ethyl]piperazin-1-yl)-2-[14-oxa-2,4,10-triazatricyclo[7.5.0.0{circumflex over ( )}[3,7]]tetradeca-1(9),2,5,7-tetraen-10-yl]phenyl]formamidosulfonyl]-2-nitrophenyl)amino]ethoxy]ethoxy)ethoxy]propanamido]-3,3-dimethylbutanoyl]-4-methyl-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide::US12220419, Example 59

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)C(C)(C)CCNC(=O)COCCOCCOCCNc2ccc(S(=O)(=O)Nc3ccc(N4CCN(C5=C(c6ccc(Cl)cc6)CC(C)(C)CC5)CC4)cc3N3CCCC(=O)c4nc5[nH]ccc5cc43)cc2[N+](=O)[O-])cc1

InChI Key InChIKey=HSOMDGVLNJEICQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719002   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM719002((2S,4R)-1-[(2S)-2-[3-[2-(2-[2-[(4-[[5-(4-[[2-(4-ch...)
Affinity DataIC50: 1.10nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent