BDBM719000 (2S,4R)-1-[(2S)-2-[1-[(4-[[4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[14-oxa-2,4,10-triazatricyclo[7.5.0.0{circumflex over ( )}[3,7]]tetradeca-1(9),2,5,7-tetraen-10-yl]phenyl]formamidosulfonyl]-2-nitrophenyl)amino]-3,6,9,12-tetraoxapentadecan-15-amido]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide::US12220419, Example 57

SMILES Cc1ccc(NS(=O)(=O)c2ccc(NCOCCOCCOCCOCC(=O)NCCC(C)(C)C(=O)N3C[C@@H](O)C[C@@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)c([N+](=O)[O-])c2)c(N2CCCC(=O)c3nc4[nH]ccc4cc32)c1

InChI Key InChIKey=JYRFJGCWWJHVQX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719000   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM719000( (2S,4R)-1-[(2S)-2-[1-[(4-[[4-(4-[[2-(4-chlorophen...)
Affinity DataIC50: 0.5nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent