BDBM718992 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-N-[(3S or 3R)-5-nitro-3-(oxan-4-yl)-3,4-dihydro-2H-1,4-benzoxazin-7-ylsulfonyl]-2-[14-oxa-2,4,10-triazatricyclo[7.5.0.0{circumflex over ( )}[3,7]]tetradeca-1(9),2,5,7-tetraen-10-yl]benzamide::US12220419, Example 46

SMILES CC1(C)CC=C(CN2CCN(c3ccc(N4CCCC(=O)c5nc6[nH]ccc6cc54)c(C(=O)NS(=O)(=O)c4cc5c(c([N+](=O)[O-])c4)N[C@@H](C4CCOCC4)CO5)c3)CC2)C(c2ccc(Cl)cc2)C1

InChI Key InChIKey=ZMMCXJRFXRYEPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718992   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718992(4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)
Affinity DataIC50: 0.600nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718992(4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)
Affinity DataIC50: 0.5nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent