BDBM718982 4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-((R)-3-methyl-2,3-dihydropyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazin-1(6H)-yl)-N-(((S)-5-nitro-3-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)sulfonyl)benzamide::US12220419, Example 37

SMILES C[C@@H]1CN(c2cc(N3CCN(CC4=C(c5ccc(Cl)cc5)CC(C)(C)CC4)CC3)ccc2C(=O)NS(=O)(=O)C2C=C([N+](=O)[O-])C3=C(C2)OC[C@H](C2CCOCC2)N3)c2cc3cc[nH]c3nc2O1

InChI Key InChIKey=JBXYALOSTCUALL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718982   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718982(4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[...)
Affinity DataIC50: 0.300nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718982(4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[...)
Affinity DataIC50: 0.5nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent