BDBM718970 4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-(3,4-dihydro-2H-pyrrolo[3',2':5,6]pyrido[2,3-b][1,4]thiazepin-1(7H)-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide::US12220419, Example 27

SMILES CC9(C)CCC(CN7CCN(c6ccc(C(=O)NS(=O)(=O)c2ccc(NCC1CCOCC1)c([N+](=O)[O-])c2)c(N5CCCSc4nc3[nH]ccc3cc45)c6)CC7)=C(c8ccc(Cl)cc8)C9

InChI Key InChIKey=LHVMQGCPIORVGJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 718970   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718970(4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[...)
Affinity DataIC50: 0.300nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent