BDBM718774 US20250042896, Compound 8

SMILES CC1CC(c2cccc(-c3cn(C)c4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1

InChI Key InChIKey=WKGIAQDXNBFTME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 718774   

TargetE3 ubiquitin-protein ligase CBL-B/(E3-independent) E2 ubiquitin-conjugating enzyme D2(Human)
Hainan Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM718774(US20250042896, Compound 8)
Affinity DataIC50: 366nMAssay Description:Experiment purpose: Testing of inhibitory activity of compounds on the interaction between Cbl-b protein and UbcH5B-Ub. Experimental method: Eu-Ubqui...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
Go to US Patent