BDBM71863 2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-methylbenzimidazole::2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1-methyl-benzimidazole::2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1-methylbenzimidazole::2-[[4-(4-chlorophenyl)piperazino]methyl]-1-methyl-benzimidazole::MLS000112495::SMR000108409::cid_798232

SMILES Cn1c(CN2CCN(CC2)c2ccc(Cl)cc2)nc2ccccc12

InChI Key InChIKey=YKMSTUDOGGAEJH-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 71863   

TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataEC50: >2.60E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataEC50:  794nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataKi:  126nMAssay Description:Antagonist activity at human D4 receptor expressed in HEK293 cells co-expressing Gqo5 G-protein by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed