BDBM718159 (R)-(5-bromo-2-((1-(isoquinolin-4-carbonyl)piperidin-3-yl)amino)-3-nitrophenyl)(piperidin-1-yl)methanone::US20250042889, Example 13

SMILES O=C(c1cc(Br)cc([N+](=O)[O-])c1N[C@@H]1CCCN(C(=O)c2cncc3ccccc23)C1)N1CCCCC1

InChI Key InChIKey=JRFMSMVXTPAESK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 718159   

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Qilu Pharmaceutical Research and Development Centre

US Patent
LigandPNGBDBM718159((R)-(5-bromo-2-((1-(isoquinolin-4-carbonyl)piperid...)
Affinity DataIC50: 30nMAssay Description:In this experiment, the activity of SARS-COV-2 3CLpro/Mpro protease was detected by fluorescence resonance energy transfer, and the half inhibitory c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
Go to US Patent